MyJournals Home  

RSS FeedsStructural Dynamics of the Paddle Motif loop in the Activated Conformation of KvAP Voltage Sensor (Biophysical Journal)

 
 

22 august 2019 20:00:28

 
Structural Dynamics of the Paddle Motif loop in the Activated Conformation of KvAP Voltage Sensor (Biophysical Journal)
 


Voltage-gated potassium (Kv) channels play a fundamental role in neuronal and cardiac excitability and are potential therapeutic targets. They assemble as tetramers with a centrally located pore-domain surrounded by a voltage-sensing domain (VSD), which is critical for sensing transmembrane potential and subsequent gating. Although the sensor is supposed to be in `Up` conformation in both n-octylglucoside (OG) micelles and phospholipid membranes in the absence of membrane potential, toxins that bind VSD and modulate the gating behaviour of Kv channels exhibit dramatic affinity differences in these membrane-mimetic systems.


 
189 viewsCategory: Biophysics
 
Multi-scale Computational Modeling of Tubulin-Tubulin Lateral Interaction (Biophysical Journal)
DNA sequence is a major determinant of tetrasome dynamics (Biophysical Journal)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Biophysics


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten