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17 september 2019 17:03:17

T Cell Activation Depends on Extracellular Alanine (Cell Reports)

In health, T lymphocytes are in a resting state. However, stimulation with their cognate antigen induces massive growth and proliferation. Ron-Harel et al. demonstrate that T cells rely on extracellular alanine for activation. Consumed alanine is used primarily for protein synthesis, and alanine deprivation inhibits T cell metabolism and effector functions.

32 viewsCategory: Cell Biology
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