The HSPG Glypican Regulates Experience-Dependent Synaptic and Behavioral Plasticity by Modulating the Non-Canonical BMP Pathway (Cell Reports)

In Drosophila, octopamine signaling increases larval locomotor speed and synaptic bouton numbers at neuromuscular junctions under food deprivation conditions. Kamimura et al. report that a glypican (Dally-like), the expression of which is controlled by octopamine signaling, regulates this process by modulating the activity of GluRIIA-mediated non-canonical BMP pathway.