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RSS FeedsMolbank, Vol. 2019, Article M1084: Reactions of Polychlorinated Pyrimidines with DABCO (Molbank)

 
 

15 october 2019 00:03:09

 
Molbank, Vol. 2019, Article M1084: Reactions of Polychlorinated Pyrimidines with DABCO (Molbank)
 


The reaction of 2,4,5,6-tetrachloropyrimidine (4) and 4,5,6-trichloropyrimidine-2-carbonitrile (1) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (5) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (6) in 42% and 52% yields, respectively. The new compounds were fully characterized.


 
146 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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