Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses (Cell Reports)

Botton et al. shed light on the heterogeneity of BRAF fusions encountered in melanocytic tumors and characterize features influencing their signaling and drug response. These findings unveil the singularities of BRAF fusions and establish general principles to guide their clinical management in melanoma and other malignancies.