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RSS FeedsMetalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate (Cell Reports)

 
 

15 october 2019 18:00:28

 
Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate (Cell Reports)
 


Arai et al. show that metalloprotease Adam19 is essential for proper differentiation of cardiac neural crest cells (CNCCs) in murine embryogenesis. Adam19 suppresses the response of CNCCs to bone morphogenic protein by cleaving its receptor Alk2, thus restricting CNCC skeletogenic potential and preventing cartilage formation in the heart.


 
166 viewsCategory: Cell Biology
 
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