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RSS FeedsInhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response (Neuron)

 
 

20 november 2019 18:01:05

 
Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response (Neuron)
 


Johnson et al. discovered that genetic ablation of Upf2-mediated NMD triggers an aberrant immune response and leads to memory, synaptic plasticity, social, and vocal communication deficits. These behavioral and neurophysiological abnormalities were reversed by FDA-approved agents that dampen brain inflammation.


 
188 viewsCategory: Neurology
 
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