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RSS FeedsMolecules, Vol. 24, Pages 4230: Total Synthesis of the Proposed Structure of Paraphaeosphaeride C (Molecules)

 
 

21 november 2019 07:03:18

 
Molecules, Vol. 24, Pages 4230: Total Synthesis of the Proposed Structure of Paraphaeosphaeride C (Molecules)
 


Paraphaeosphaeride C is a demethoxy derivative of phaeosphaeride A and exhibits STAT3 inhibitory activity. Our previous papers reported the total synthesis of phaeosphaeride A using a diastereoselective vinyl anion aldol reaction as the key step to construct the dihydropyran ring. In this work, the first total synthesis of the proposed structure of paraphaeosphaeride C was achieved via a similar synthetic strategy. The synthetic compound was characterized through extensive nuclear magnetic resonance (NMR) analysis but the 1H and 13C-NMR data for this compound did not correspond to those reported in the literature for paraphaeosphaeride C.


 
369 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
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Molecules, Vol. 24, Pages 4229: Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application (Molecules)
 
 
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