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RSS FeedsA Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells (Molecular Cell)

 
 

21 november 2019 20:00:54

 
A Complex of U1 snRNP with Cleavage and Polyadenylation Factors Controls Telescripting, Regulating mRNA Transcription in Human Cells (Molecular Cell)
 


So etáal. show that a complex of U1 snRNP (U1) with cleavage and polyadenylation factors (CPAFs) binds pre-mRNAs` cryptic polyadenylation signals, suppressing premature transcription termination and linking multiple mRNA processing and transcription factors. U1 PAS suppression, called telescripting, is required for full-length transcription and regulates 3┤ UTR length.


 
70 viewsCategory: Molecular Biology, Cell Biology
 
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