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RSS FeedsRepurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis (Structure)

 
 

7 january 2020 18:03:46

 
Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis (Structure)
 


Most GCN5-related N-acetyltransferase (GNAT) superfamily members catalyze acyltransfer, but some are decarboxylases. Skiba et al. show that `GNATs` involved in the biosynthesis of two polyketide natural products catalyze only decarboxylation. They identify GNAT-like decarboxylases on distant nodes of the superfamily, illustrating the adaptability of the GNAT fold.


 
151 viewsCategory: Biochemistry
 
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