Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism (Cell Reports)

Differential susceptibilities of bats to filoviruses have been suggested. Takadate et al. compare structures of the filovirus receptor among a variety of bat cell lines and discover a molecular mechanism determining their susceptibility to Ebola and Marburg viruses, providing information for understanding the ecology of filoviruses.