Specific Ion Channels Control Sensory Gain, Sensitivity, and Kinetics in a Tonic Thermonociceptor (Cell Reports)

Saro et al. ask how sensory information is encoded in a tonic thermonociceptor neuron. The work highlights a distribution of tasks among different ion channels controlling the detection, amplification, stabilization, and termination of signals and reveals the importance of their orchestration to control short- and long-term aversive behaviors.