MyJournals Home  

RSS FeedsViruses, Vol. 12, Pages 113: Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis (Viruses)

 
 

16 january 2020 15:04:45

 
Viruses, Vol. 12, Pages 113: Interferon-Gamma Modulation of the Local T Cell Response to Alphavirus Encephalomyelitis (Viruses)
 


Infection of mice with Sindbis virus (SINV) provides a model for examining the role of the immune response to alphavirus infection of the central nervous system (CNS). Interferon-gamma (IFN-γ) is an important component of this response, and we show that SINV-infected differentiated neurons respond to IFN-γ in vitro by induction of antiviral genes and suppression of virus replication. To determine the in vivo effects of IFN-γ on SINV clearance and T cell responses, C57BL/6 mice lacking IFN-γ or IFN-γ receptor-1 were compared to wild-type (WT) mice after intracranial SINV infection. In WT mice, IFN-γ was first produced in the CNS by natural killer cells and then by CD4+ and CD8+ T cells. Mice with impaired IFN-γ signaling initiated clearance of viral RNA earlier than WT mice associated with CNS item of more granzyme B-producing CD8+ T cells. However, these mice established fewer CD8+ tissue-resident memory T (TRM) cells and were more likely to experience reactivation of viral RNA synthesis late after infection. Therefore, IFN-γ suppresses the local development of granzyme B-expressing CD8+ T cells and slows viral RNA clearance but promotes CD8+ TRM cell establishment.


 
226 viewsCategory: Epidemiology, Virology
 
Viruses, Vol. 12, Pages 106: Modeling Challenges of Ebola Virus-Host Dynamics during Infection and Treatment (Viruses)
Viruses, Vol. 12, Pages 112: Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells (Viruses)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Virology


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten