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16 january 2020 18:00:46

 
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9 (Cell Chemical Biology)
 


Petrilli et al. describe the identification of high-affinity small-molecule binders to PCSK9 through two complementary hit-to-lead approaches. The lead compound was shown to bind to PCSK9 in a cellular thermal shift assay and subsequently developed into a targeted protein degrader.


 
56 viewsCategory: Biology, Chemistry, Biochemistry
 
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