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RSS FeedsEED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex (Cell Chemical Biology)

 
 

16 january 2020 18:00:46

 
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex (Cell Chemical Biology)
 


Hsu et al. describe the discovery of EED-targeted PROTACs that lead to the degradation of multiple components of the PRC2 complex. Furthermore, they demonstrate that these PROTACs inhibit the proliferation of PRC2-dependent cancer cells and may be considered an attractive alternative to EZH2 catalytic inhibitors currently in clinical development.


 
62 viewsCategory: Biology, Chemistry, Biochemistry
 
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