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RSS FeedsDegradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader (Cell Chemical Biology)

 
 

16 january 2020 18:00:46

 
Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader (Cell Chemical Biology)
 


Using an EED-targeted chemical degrader, Potjewyd et al. demonstrate successful degradation of the PRC2 complex. UNC6852 provides a unique tool to study PRC2 function and downregulation of PRC2 activity in cancer and demonstrates the feasibility of developing PRC2-targeted degraders as potential therapeutics.


 
61 viewsCategory: Biology, Chemistry, Biochemistry
 
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex (Cell Chemical Biology)
Development and Characterization of a Wee1 Kinase Degrader (Cell Chemical Biology)
 
 
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