MyJournals Home  

RSS FeedsDiscovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling (Cell Chemical Biology)

 
 

16 january 2020 18:00:46

 
Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling (Cell Chemical Biology)
 


You and Erickson et al. report the development and characterization of INY-03-041, a highly selective AKT degrader. The authors demonstrate that INY-03-041 not only exhibits more potent anti-proliferative effects than the catalytic inhibitor GDC-0068, but also induces sustained AKT destabilization and inhibition of downstream signaling, even after compound washout.


 
173 viewsCategory: Biology, Chemistry, Biochemistry
 
Development and Characterization of a Wee1 Kinase Degrader (Cell Chemical Biology)
Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases (Cell Chemical Biology)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Biochemistry


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten