Biochemistry
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16 january 2020 18:00:46 |
| Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases (Cell Chemical Biology) |
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Tweet Activity-based probes (ABPs) are valuable research tools for studying enzyme function. Ubiquitin E3 ligases are one of the largest enzyme families yet ABPs for this enzyme class do not exist. Mathur et al. developed photocrosslinking ABPs for RING E3s and using activity-based proteomics demonstrate activity-dependent readout of diverse E3 activation. |
| 213 viewsCategory: Biology, Chemistry, Biochemistry |
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