Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy (Cell Chemical Biology)

Koch et al. describe the development of LCL161 nanoparticles for cancer immunotherapy. These nanoparticles deliver the small-molecule drug LCL161 to intratumoral dendritic cells, where it stimulates production of IL-12. This therapeutic could greatly enhance the efficacy of current checkpoint inhibitors.