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RSS FeedsClofarabine Commandeers the RNR-?-ZRANB3 Nuclear Signaling Axis (Cell Chemical Biology)

 
 

16 january 2020 18:00:46

 
Clofarabine Commandeers the RNR-?-ZRANB3 Nuclear Signaling Axis (Cell Chemical Biology)
 


Regulators of Ras oncogenic signaling, particularly non-essential genes, are critically important targets for drug discovery. Long et al. show that ZRANB3, a non-essential gene, is required for H-Ras-induced focus formation. This process is inhibited by an RNR-?-targeting drug, clofarabine that promotes RNR-? nuclear translocation, thereby ushering previously unrecognized therapeutic opportunities.


 
38 viewsCategory: Biology, Chemistry, Biochemistry
 
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