MeCP2 Represses Enhancers through Chromosome Topology-Associated DNA Methylation (Molecular Cell)

Clemens and Wu et al. demonstrate that DNMT3A establishes non-CG DNA methylation across topologically associating domains in neurons, resulting in broad regions of high and low methylation. Within regions of enriched DNA methylation, MeCP2 represses the activity of enhancers, regulating promoter activation for genes controlled by these enhancers.