MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading (Molecular Cell)

The recovery of stalled replication forks depends on extensive modifications of the fork structure and on the loading of cohesin. Delamarre et al. report that Mre11-Rad50-Xrs2 (MRX) cooperates with chromatin modifiers and remodelers to promote the long-range resection of nascent DNA. Extensive fork resection is required to recruit cohesin and to promote a fork restart.