This paper focuses on the presentation of an integrated framework based on two advanced strategies, aimed at mitigating the effect of traffic congestion in terms of performance and environmental impact. In particular, the paper investigates the “operational benefits” that can be derived from the combination of traffic control (TC) and route guidance (RG) strategies. The framework is based on two modules and integrates a within-day traffic control method and a day-to-day behavioral route choice model. The former module consists of an enhanced traffic control model that can be applied to design traffic signal decision variables, suitable for real-time optimization. The latter designs the information consistently with predictive user reactions to the information itself. The proposed framework is implemented to a highly congested sub-network in the city center of Naples (Italy) and different scenarios are tested and compared. The “do nothing” scenario (current; DN) and the “modeled compliance” (MC) scenario, in which travelers’ reaction to the information (i.e., compliance) is explicitly represented. In order to evaluate the effectiveness of the proposed strategy and the modeling framework, the following analyses are carried out: (i) Network performance analysis; (ii) system convergence and stability analysis, as well as the compliance evolution over time; (iii) and emissions and fuel consumption impact analysis.