A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53 (Cell Reports)

Knockin of the mouse homolog of a human TP53 germline mutation known to cause Li-Fraumeni syndrome, a cancer predisposition disorder, results in a mouse model characterized by lower body fat content. Kang et al. show that enhancing transactivation of the lipolytic gene ADRB3 by mutant p53 contributes to this phenotype.