Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation (Cell Reports)

Ma et al. demonstrate that fibroblast-derived periostin promotes colorectal tumorigenesis by enhancing YAP/TAZ nuclear localization and IL-6 expression in tumor cells. Conversely, IL-6 promotes periostin expression in fibroblasts via STAT3 signaling. This work identifies crosstalk between stromal cells and tumor cells via periostin and IL-6 during colorectal tumorigenesis.