Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells (Cell Reports)

Nickolls et al. develop a method, using human stem cells, to generate specific types of sensory neurons that detect cold temperature and mechanical force. This approach uncovers a class of neuron found in humans, but not mice, and enables the modeling of a rare sensory disorder of touch and proprioception.