On the Long and Winding Road to a Perfect Membrane Model (Biophysical Journal)

Molecular interactions at and within cellular membranes are at the heart of many biological processes. Studying these interactions in their native environment is often challenging because of the inherent complexity of the cellular milieu. Model systems can fill a crucial niche by simplifying the interactome to a few key components, enabling elucidation of the functional contribution of different factors by systematically varying parameters of interest.