MyJournals Home  

RSS FeedsDocking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments (Biophysical Journal)

 
 

21 january 2020 22:00:19

 
Docking Troponin T onto the Tropomyosin Overlapping Domain of Thin Filaments (Biophysical Journal)
 


Complete description of thin filament conformational transitions accompanying muscle regulation requires ready access to atomic structures of actin-bound tropomyosin-troponin. To date, several molecular-docking protocols have been employed to identify troponin interactions on actin-tropomyosin because high-resolution experimentally determined structures of filament-associated troponin are not available. However, previously published all-atom models of the thin filament show chain separation and corruption of components during our molecular dynamics simulations of the models, implying artifactual subunit organization, possibly due to incorporation of unorthodox tropomyosin-TnT crystal structures and complex FRET measurements during model construction.


 
141 viewsCategory: Biophysics
 
A Mechanistic View of Collective Filament Motion in Active Nematic Networks (Biophysical Journal)
PSI-SMALP, a Detergent-free Cyanobacterial Photosystem I, Reveals Faster Femtosecond Photochemistry (Biophysical Journal)
 
 
blog comments powered by Disqus


MyJournals.org
The latest issues of all your favorite science journals on one page

Username:
Password:

Register | Retrieve

Search:

Biophysics


Copyright © 2008 - 2024 Indigonet Services B.V.. Contact: Tim Hulsen. Read here our privacy notice.
Other websites of Indigonet Services B.V.: Nieuws Vacatures News Tweets Nachrichten