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RSS FeedsIJMS, Vol. 21, Pages 733: Genome Editing for the Understanding and Treatment of Inherited Cardiomyopathies (International Journal of Molecular Sciences)

 
 

23 january 2020 02:02:39

 
IJMS, Vol. 21, Pages 733: Genome Editing for the Understanding and Treatment of Inherited Cardiomyopathies (International Journal of Molecular Sciences)
 


Cardiomyopathies are diseases of heart muscle, a significant percentage of which are genetic in origin. Cardiomyopathies can be classified as dilated, hypertrophic, restrictive, arrhythmogenic right ventricular or left ventricular non-compaction, although mixed morphologies are possible. A subset of neuromuscular disorders, notably Duchenne and Becker muscular dystrophies, are also characterized by cardiomyopathy aside from skeletal myopathy. The global burden of cardiomyopathies is certainly high, necessitating further research and novel therapies. Genome editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats (CRISPR) systems have emerged as increasingly important technologies in studying this group of cardiovascular disorders. In this review, we discuss the applications of genome editing in the understanding and treatment of cardiomyopathy. We also describe recent advances in genome editing that may help improve these applications, and some future prospects for genome editing in cardiomyopathy treatment.


 
209 viewsCategory: Biochemistry, Biophysics, Molecular Biology
 
IJMS, Vol. 21, Pages 734: Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica (International Journal of Molecular Sciences)
IJMS, Vol. 21, Pages 732: Advances in HDL: Much More than Lipid Transporters (International Journal of Molecular Sciences)
 
 
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