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RSS FeedsMarine Drugs, Vol. 18, Pages 71: Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272 (Marine Drugs)

 
 

23 january 2020 12:03:08

 
Marine Drugs, Vol. 18, Pages 71: Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272 (Marine Drugs)
 


Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL.


 
212 viewsCategory: Biochemistry, Molecular Biology, Pharmacology
 
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