Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade (Developmental Cell)

Liu et al. demonstrate that, whereas consumption of high-level palmitate (the major saturated fatty acid in the human diet) induced lipotoxic effects, consumption of low-level palmitate enhanced mitochondrial metabolism and compromised both high-level-palmitate-induced lipotoxicity and CCl4-generated hepatotoxicity via a CDK1-SIRT3-CPT2 cascade.