Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection (Cell Reports)

Kräutler et al. compare the evolutions of antibody responses during acute or chronic lymphocytic choriomeningitis (LCMV) infection by combining quantitative functional assays and time-resolved antibody repertoire sequencing. They reveal sustained germinal center (GC) reactions and plasma cell differentiation during chronic infection, leading to the emergence of a personalized antibody repertoire containing infection-resolving antibodies.