Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration (Cell Reports)

Piao et al. demonstrate that Tregs condition lymphatic endothelial cells (LECs) to be more permissive for the transendothelial migration (TEM) of other leukocytes. Activation of Toll-like receptor 2 on Tregs during inflammation specifically augments Treg LT?1?2 expression to intensify LT?R signaling in LECs for enhanced immune cell TEM.