hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation (Cell Reports)

Batlle et al. show that alternative splicing controls heterogeneous ribonucleoprotein D-like (hnRNPDL) phase separation, aggregation, and solubility. Mutations that cause LGMD1G accelerate hnRNPDL aggregation and promote insolubility in Drosophila.