TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation (Cell Reports)

Suter et al. demonstrate that the motor neuron cell surface molecule TAG-1 confines motor neurons to the central nervous system, promotes motor axon fasciculation, and steers motor axons past inappropriate targets. This study highlights how a single cell adhesion molecule coordinates multiple steps in neuronal wiring through partially divergent mechanisms.