Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes (Cell Reports)

Alabert et al. introduce a computational model to describe the propagation of histone K27 and K36 methylations on successive generations of histones. This quantitative model invokes the existence of domains with distinct methylation endpoints and reveals that antagonisms between histone methylations enhance the stability of epigenetic states.