This Special Issue of the Energies Journal on Deep Borehole Disposal of Nuclear Waste has delivered a timely update on the science and technology of borehole disposal and the types of radioactive wastes it could potentially accommodate. The Special Issue papers discuss (i) circumstances under which a national waste management programme might wish to consider deep borehole disposal; (ii) a status report of deep borehole disposal options in Germany; (iii) the analysis of corrosion performance of engineered barrier systems; (iv) a review of the potential cementing systems suitable for deep borehole disposal; (v) the thermal evolution around heat-generating waste for a wide range of material properties and disposal configurations; (vi) a geochemical analysis of deep brines focussed on fluid-rock interactions; (vii) post-closure performance assessment calculations for deep borehole disposal of Cs/Sr capsules and an example safety case for (viii) horizontal and (ix) vertical deep borehole disposal of nuclear wastes.