Examination plays a vital role in the present contemporary educational setting as well as serving as an indicator and yardstick to place students in relation to their examination scores after they undergo the examination. However, students at different educational levels experience examination anxiety, which can interfere with making right decisions either before or during examinations and is considered to be a phenomenon associated with low examination scores. Therefore, the present research study was aimed at determining the mediating effect of positive psychological strengths between study skills and examination anxiety among Nigerian college students. The study employed survey research on 315 Nigerian college students. The result of the path analysis shows that study skills (SSK) have a significant and direct relationship on examination anxiety. The mediation between positive psychological strength (PPS) and examination anxiety is identified as being effective and significant. Therefore, positive psychological strength (PPS) acts as an effective mediator towards examination anxiety.