Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation (Immunity)

Mast cell functions beyond allergic diseases remain enigmatic. To provide structural information, Plum et al. performed comprehensive proteome analyses on primary human and mouse mast cells, revealing the cells` unique lineage within the immune system, putative roles in neuroimmune interactions, and targets for antibody-mediated mast cell ablation.