Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming (Cell Reports)

By monitoring activation kinetics of Tet1 and Oct4 cell state-specific regulatory elements, Bartoccetti et al. identify phases of gene expression changes uncoupled from two waves of global DNA demethylation late in reprogramming. Stage-specific functions of TET1 regulate germline regulators during reprogramming and somatic lineage genes during maintenance of pluripotency.