The Natural Metabolite 4-Cresol Improves Glucose Homeostasis and Enhances ?-Cell Function (Cell Reports)

Brial et al. identify the inverse correlation between diabetes and serum 4-cresol, a metabolite present in the environment and produced by intestinal bacteria. The administration of 4-cresol in models of diabetes reduces obesity and liver fat, improves glycemic control, and stimulates insulin secretion and ?-cell proliferation.