Salvage Treatment for Biochemical Failure After Radical Prostatectomy: Do We Now Have the Answers? (European Urology)

Since the reports nearly 15 yr ago on three randomised trials (EORTC trial 2291, SWOG8794, and ARO 96-02) supporting the use of adjuvant radiation therapy (RT) to the prostate bed after radical prostatectomy (RP) for patients with high-risk prostate cancer, there has been a paucity of randomised trials to guide clinicians on the best management of a prostate-specific antigen (PSA) failure after RP. The exceptions have been two studies suggesting a benefit of adding androgen deprivation (ADT) to prostate-bed RT [1,2].