Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery (Cell Chemical Biology)

Murithi et al. designed a high-throughput assay to profile the Plasmodium falciparum asexual blood stage parasites against which antimalarial candidates are maximally active. These data combined with metabolomics fingerprinting provide valuable insights into the mode of action of clinical and experimental antimalarials, and helped prioritize compounds for further development.