Aptamers as Reversible Sorting Ligands for Preparation of Cells in Their Native State (Cell Chemical Biology)

Cell purification methods rely upon poorly reversible antibody labeling of desired cells or upon depletion of unwanted cells. Powell Gray et al. demonstrate that aptamers can be used to positively purify cells and, unlike antibodies, yield cells in their native state using antidote-mediated reversal of aptamer cell-surface binding.