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20 february 2020 18:00:27

 
A Strategic Approach for Fluorescence Imaging of Membrane Proteins in a Native-like Environment (Cell Chemical Biology)
 


Membrane proteins are challenging targets for detailed biophysical analysis. Here, Swiecicki et al. apply an integrated approach involving unnatural amino acid mutagenesis, bioorthogonal labeling and detergent-free membrane protein solubilization based on an amphipathic polymer. When combined, these technologies deliver uniquely labeled membrane proteins in a native-like lipid bilayer for fluorescence-based studies.


 
152 viewsCategory: Biology, Chemistry, Biochemistry
 
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