HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity (Molecular Cell)

Bacteria possess a variety of mechanisms to protect themselves against phage infection. Here, Ye et al. describe the molecular mechanisms of the newly described CBASS pathway and show how this pathway kills infected cells through activation of a nuclease. This `abortive infection` mechanism protects the bacterial population by aborting bacteriophage replication.