Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense (Molecular Cell)

Viperin potently inhibits a broad spectrum of viruses. Yuan et al. show that Viperin protein induction in epithelium during viral infection is disrupted by the HAT1-UBE4A axis that results in Viperin acetylation and subsequent ubiquitination, and interfering peptides VIP-IP3 can restore Viperin protein and enhance epithelial antiviral defense.