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21 february 2020 02:03:02

 
Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2? (Molecular Cell)
 


Klann et al. developed a proteomics method that uses signal amplification to enable acute translation measurements. Employing this method, they reveal that the integrated stress response and mTORC1 inhibit translation of the same set of proteins. Target specificity is defined by global translation attenuation in a dose-dependent manner.


 
184 viewsCategory: Molecular Biology, Cell Biology
 
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