Non-enzymatic Activity of the ?-Tubulin Acetyltransferase ?TAT Limits Synaptic Bouton Growth in Neurons (Current Biology)

Blending in vivo and in vitro reconstitution approaches, Coombes and Saunders et al. reveal that ?-tubulin acetyltransferase uses its non-enzymatic activity to curb synaptic terminal growth in neurons. Non-enzymatic ?TAT activity accelerates microtubule tip structure aging, which selectively destabilizes dynamic, but not stable, microtubules.