UBAP2L Forms Distinct Cores that Act in Nucleating Stress Granules Upstream of G3BP1 (Current Biology)

Stress granules (SGs) are formed by a stable core and a dynamic shell. Cirillo, Cieren, et al. demonstrate that UBAP2L is an SG core component that does not always colocalize with the previously identified core protein G3BP1. UBAP2L is required for SG formation in several stress conditions and forms SGs independent and upstream of G3BP proteins.